ResQBand Library
Trial recruiting · ClinicalTrials.gov · Oct 8
Ages babies and up · Sites in 1 US state
Peanut allergy is the most common cause of fatal and near-fatal food-allergic reactions and egg allergy is among the two most common causes of food-induced anaphylaxis.
Study · Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · Oct 2
Goto K, Nagakura KI, Fusayasu N, et al.
Background: The natural history of peanut allergy based on oral food challenge (OFC) outcomes has been rarely reported. We investigated the clinical course of peanut allergy up to 12 years of age using OFC results.
Study · Cellular and molecular gastroenterology and hepatology · Sep 30
Clough KM, Gomez-Martinez I, Cannon G, et al.
Background and aims: A growing body of evidence links intestinal epithelial cell barrier dysfunction to the development of food allergies. We previously showed that the peanut allergy-susceptible CC027 mouse has increased intestinal permeability.
Trial recruiting · ClinicalTrials.gov · Sep 16
Phase 2 · Ages 12 to 55 · Sites in 9 US states
The proposed study is a proof-of-concept Phase 2, double-blind, randomized placebo-controlled clinical trial evaluating the safety and efficacy of tezepelumab and peanut Oral Immunotherapy (OIT) for the treatment of peanut allergy.
Trial recruiting · ClinicalTrials.gov · Aug 25
Phase 1 · Ages 12 to 55 · Sites in 6 US states
The goal of this clinical trial is to evaluate the safety, pharmacokinetics, and effectiveness of MY006, a therapy designed to prevent severe or potentially life-threatening allergic reactions caused by accidental peanut intake.
Study · Allergy · Sep 30
Simard ML, Braun C, Antony É, et al.
Background: Unmet needs remain for disease-modifying interventions for the treatment of severe persistent food allergies.
Trial recruiting · ClinicalTrials.gov · Apr 24
Phase 1/2 · Ages 14 to 50 · Sites in 1 US state
This is a Phase 1/2 study to evaluate the safety and clinical activity of ENP-501 in non-peanut allergic (NPA) healthy participants and participants with an established peanut allergy (PA) Conditions: Peanut Allergy. Tested: ENP-501, Placebo.
Study · The journal of allergy and clinical immunology. In practice · Sep 17
Brettig TW, McDonald E, West D, et al.
Background: Oral immunotherapy (OIT) practices for food allergy vary globally. Whereas oral food challenges (OFCs) are not routinely performed before OIT, they can prevent unnecessary treatment.
Study · Gut microbes · Oct 8
Shannon E, Devotta H, Ndwandwe C, et al.
Early life introduction of potentially allergenic foods such as peanuts is important for the prevention of food allergy.
Trial recruiting · ClinicalTrials.gov · Sep 25
Phase 3 · Ages 12 to 65 · Sites in 12 US states
The purpose of this Phase III study is to evaluate the clinical efficacy and safety of remibrutinib in participants with peanut, or cow's milk ("milk", cooked and uncooked) or hen's egg ("egg", cooked and uncooked) immunoglobulin E (IgE)- mediated allergy in…
Study · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · Sep 27
Liu M, Zhang B, Wang J, et al.
5-fold increase in incidence in the past two decades. However, disease-modifying therapies remain limited due to incomplete understanding of the underlying metabolic mechanisms.
Review · Nutrients · Sep 16
Rogalidou M, Siahanidou T
Background: Food allergy is an important health concern, particularly during infancy and early childhood.
Review · Frontiers in immunology · Sep 14
Song C, Zhang Q, Li Z, et al.
Food allergy is an immune-mediated condition associated with acute reactions, risk of anaphylaxis, and a substantial day-to-day management burden.
Review · Journal of clinical medicine · Sep 14
Turkalj M, Banić I
Allergen-specific immunotherapy (AIT) is a well-proven treatment for allergic diseases and conditions such as Hymenoptera venom allergy, allergic rhinitis, allergic asthma, and, in recent years, food allergy.
Study · bioRxiv : the preprint server for biology · Sep 9
Chang YT, Le HH, Morrison A, et al.
Dietary proteins induce antigen-specific immune responses, leading to oral tolerance or food allergies.
Trial recruiting · ClinicalTrials.gov · Aug 26
Phase 2 · Ages 3 to 21 · Sites in 1 US state
Background: Atopic dermatitis (AD), also called eczema, makes skin dry, red, and itchy. People with AD are more likely to get a food allergy than people without AD. But some food allergy tests are not always accurate in people with AD.
Trial recruiting · ClinicalTrials.gov · Jul 28
Phase 2 · Ages 12 to 55 · Sites in British Columbia, Ontario, Quebec, and in 16 US states
Phase 2b Study of RPT904 as Monotherapy in Participants With IgE-Mediated Food Allergy: This is a Phase 2b randomized, double-blind, placebo-controlled clinical trial evaluating RPT904, a next-generation anti-IgE monoclonal antibody, in people with food…
Trial recruiting · ClinicalTrials.gov · Jul 14
Phase 1 · Ages 18 to 55 · Sites in Ontario
This is a Phase 1combined single ascending dose (SAD)/multiple ascending dose (MAD) randomized, double-blind, placebo-controlled trial to assess the safety, tolerability, pharmacokinetics, pharmacodynamics, and immunogenicity of single and multiple ascending…
Trial recruiting · ClinicalTrials.gov · May 7
Ages 2 to 40 · Sites in Quebec
Protocols for Oral Immunotherapy (OIT) for the main food allergens have been recently incorporated in clinical practice for food allergies and their clinical benefits have been acknowledged in European and Canadian official guidelines.
