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Results for “Oral immunotherapy”

News, research, episodes and posts (23)

Study · The journal of allergy and clinical immunology. In practice · Sep 17
An Oral Food Challenge Is Required for Accurate Diagnosis of Peanut Allergy in Infants Prior to Oral Immunotherapy: Evaluation of the Allergy Development to an Accelerated Pathway to Tolerance Peanut Oral Immunotherapy Program (opens in a new tab)
Brettig TW, McDonald E, West D, et al.
Background: Oral immunotherapy (OIT) practices for food allergy vary globally. Whereas oral food challenges (OFCs) are not routinely performed before OIT, they can prevent unnecessary treatment.
ResearchOral immunotherapyTreatments
Trial recruiting · ClinicalTrials.gov · Sep 16
Efficacy of Tezepelumab in Peanut Oral Immunotherapy (opens in a new tab)
Phase 2 · Ages 12 to 55 · Sites in 9 US states
The proposed study is a proof-of-concept Phase 2, double-blind, randomized placebo-controlled clinical trial evaluating the safety and efficacy of tezepelumab and peanut Oral Immunotherapy (OIT) for the treatment of peanut allergy.
ResearchOral immunotherapyTreatments
Trial recruiting · ClinicalTrials.gov · May 7
Investigating Modified Protocols of Oral Immunotherapy to Validate Efficacy and Safety (opens in a new tab)
Ages 2 to 40 · Sites in Quebec
Protocols for Oral Immunotherapy (OIT) for the main food allergens have been recently incorporated in clinical practice for food allergies and their clinical benefits have been acknowledged in European and Canadian official guidelines.
ResearchOral immunotherapyTreatments
Study · Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · Oct 2
Inhibition studies to direct oral immunotherapy in walnut-hazelnut co-allergic patients (nut CRACKER study) (opens in a new tab)
Koren Y, Appel MY, Elkan M, et al.
Background: Walnut OIT has been observed to induce cross-desensitization to hazelnut, but predictors of this response remain unclear.
ResearchOral immunotherapyTreatments
Study · Allergy · Sep 30
Efficacy and Safety of Abatacept Versus Placebo During Peanut Oral Immunotherapy for Adults With Severe Peanut Allergy (opens in a new tab)
Simard ML, Braun C, Antony É, et al.
Background: Unmet needs remain for disease-modifying interventions for the treatment of severe persistent food allergies.
ResearchOral immunotherapyTreatments
Trial recruiting · ClinicalTrials.gov · Aug 10
Effects of Inhaled Epinephrine on Systemic Allergic Reactions During Allergy Testing, Immunotherapy or Oral Challenges (opens in a new tab)
Phase 1 · Ages 12 and up · Sites in British Columbia
The goal of this exploratory study is to evaluate the effects of inhaled epinephrine in subjects, who may not be eligible for the GHL-101 trial, and who are experiencing systemic allergic reaction (SAR) that occur following allergy testing, subcutaneous…
ResearchOral immunotherapyTreatments
Review · Journal of clinical medicine · Sep 14
Indications for Biological Treatment Combined with Allergen-Specific Immunotherapy: Who Is It Really Intended for? (opens in a new tab)
Turkalj M, Banić I
Allergen-specific immunotherapy (AIT) is a well-proven treatment for allergic diseases and conditions such as Hymenoptera venom allergy, allergic rhinitis, allergic asthma, and, in recent years, food allergy.
ResearchOral immunotherapyTreatments
Review · Clinical and translational allergy · Sep 29
Sesame Immunotherapy: A Systematic Review and Narrative Synthesis (opens in a new tab)
Zielińska J, Kunkiel K, Krupa-Łaska A, et al.
Sesame allergy is associated with severe allergic reactions, low rates of spontaneous resolution, and significant psychosocial burden. Current management relies on strict avoidance and emergency treatment.
ResearchOral immunotherapyTreatments
Study · Journal of clinical apheresis · Oct 6
Safety and Efficacy of Selective Plasma Exchange Versus Conventional Plasma Exchange in Pretransplant Desensitization of ABO-Incompatible Kidney Transplantation (opens in a new tab)
Inoue T, Hirano H, Munakata Y, et al.
Selective plasma exchange (SePE) may reduce adverse events associated with fresh frozen plasma (FFP) use during pretransplant desensitization for ABO-incompatible kidney transplantation.
ResearchOral immunotherapy
Study · Naunyn-Schmiedeberg's archives of pharmacology · Sep 30
Hypersensitivity reactions to pertuzumab/trastuzumab fixed-dose combination (PHESGO®): successful management with a simplified 9-step subcutaneous desensitization protocol (opens in a new tab)
Cristallo M, Filieri M, Stucci LS, et al.
Hypersensitivity reactions (HSRs) to anti-HER2 monoclonal antibodies may limit access to optimal therapy in HER2-positive breast cancer.
ResearchOral immunotherapyTreatments
Review · Current allergy and asthma reports · Sep 28
Hypersensitivity Reactions to Biologics: Advances in Diagnosis and Management (opens in a new tab)
Yang BC
Purpose of review: The landscape of biologic therapeutics has expanded to include therapies such as antibody-drug conjugates (ADCs) and bispecific T-cell engagers.
ResearchOral immunotherapyTreatments
Study · The journal of allergy and clinical immunology. In practice · Sep 24
The Impact of Dupilumab Treatment on the Management of Co-Morbid Food Allergy (opens in a new tab)
Hua A, Dong S, Kim KY, et al.
Background: Studies demonstrate that dupilumab treatment decreases food-specific IgE (sIgE) but this has not been shown to correlate with clinical desensitization.
ResearchOral immunotherapyTreatments
Review · Frontiers in immunology · Sep 14
Beyond desensitization: the SCFA-Treg-gut microbiota axis as a mechanistic framework for sustained unresponsiveness in food allergy (opens in a new tab)
Song C, Zhang Q, Li Z, et al.
Food allergy is an immune-mediated condition associated with acute reactions, risk of anaphylaxis, and a substantial day-to-day management burden.
ResearchOral immunotherapyTreatments
Review · Immunology and allergy clinics of North America · Aug 5
New and Emerging Treatments of Food Allergy (opens in a new tab)
Bjelac J, Silvers S, Schroer B
Immunoglobulin E (IgE)-mediated food allergy (FA) affects millions worldwide and imposes significant health, economic, and psychosocial burdens. Historically, management relied on allergen avoidance and emergency treatment, leaving patients at persistent risk.
ResearchOral immunotherapyTreatments
Trial recruiting · ClinicalTrials.gov · Apr 21
Study Evaluating the Safety and Efficacy of Neffy or Intramuscular Adrenalin in Patients With Allergic Reactions After Oral Food Challenge or Allergen Immunotherapy (opens in a new tab)
Phase 4 · Ages 4 and up · Sites in 6 US states
The study is to assess the safety of neffy or IM Adrenalin in patients who are experiencing allergic reactions after an OFC, allergen Immunotherapy (AIT), or other allergy challenge that may require epinephrine intervention. Conditions: Allergic Reactions.
ResearchTreatmentsEpinephrine
Trial recruiting · ClinicalTrials.gov · Oct 8
Beginning to Assess an Appropriate CONtrol for Oral Food Challenges in Alpha-Gal Syndrome (CoFAR-13) - BeACON4AG (opens in a new tab)
Phase 2 · Ages 12 to 50 · Sites in 4 US states
This is a multisite, randomized, double-blind, controlled cross-over trial with detailed characterization of participants with varying clinical sub-phenotypes of Alpha-gal Syndrome (AGS) who are then evaluated by oral food challenges with alpha-gal Knock Out…
ResearchTesting and diagnosis
Study · Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · Oct 2
Peanut allergy prognosis up to age 12: Oral food challenge-based study in Japanese children (opens in a new tab)
Goto K, Nagakura KI, Fusayasu N, et al.
Background: The natural history of peanut allergy based on oral food challenge (OFC) outcomes has been rarely reported. We investigated the clinical course of peanut allergy up to 12 years of age using OFC results.
ResearchTesting and diagnosis
Study · International archives of allergy and immunology · Oct 7
Clinical and Immunological Determinants of Time to Open Oral Food Challenge-Confirmed Tolerance in Children With IgE-Mediated Food Allergy: A Retrospective Cohort Study (opens in a new tab)
Kangalli Boyacioglu O, Soyöz Ö, Erdem Bahçeci S
Background: The timing of tolerance acquisition in childhood IgE-mediated food allergy is clinically important but has been less well studied than persistence as a binary outcome.
ResearchTesting and diagnosis
Study · Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · Sep 24
Vespula spp. venom immunotherapy: basophil excitability and Fc ε RI/Fc γ RIIb expression (opens in a new tab)
Fleissner J, Stoevesandt J, Goebeler M, et al.
Background: Basophils are recognized as important effector cells during the sensitization and effector phases of IgE-mediated allergy.
ResearchTreatmentsTesting and diagnosis
Study · Allergy, asthma & immunology research · Oct 8
Efficacy of Starting Very-Low-Dose Cow's Milk Intake in Children Aged 1-12 Years With Severe Cow's Milk Allergy: A Retrospective Study (opens in a new tab)
Yamashita K, Imai T, Seki S, et al.
Purpose: To avoid the complete elimination of cow's milk (CM) from the diet, we introduced a very-low-dose (VLD) oral food challenge (OFC) as part of an OFC-based stepwise ingestion protocol in patients with severe CM allergy in 2019, when the OFC protocol…
ResearchTesting and diagnosis
Review · The journal of allergy and clinical immunology. In practice · Oct 7
Understanding and Leveraging Implementation Science Within a Clinical Informatics Framework for Allergy/Immunology (opens in a new tab)
Nordness M, Nyenhuis SM, Rider NL, et al.
The integration of research discoveries into routine clinical care is often slow and resource-intensive, particularly in allergy and immunology, where advances in biologics, immunotherapy, precision diagnostics, and guideline-driven management continue to…
ResearchTreatmentsTesting and diagnosis
Study · Medicine · Sep 19
Efficacy of probiotics combined with tacrolimus ointment in children with atopic dermatitis and its effects on serum IgE, IL-4, and LTB4: A single-center retrospective cohort study (opens in a new tab)
Zhu J, Bu D
This study evaluates the clinical efficacy and safety of adding an oral probiotic preparation to tacrolimus ointment in children with atopic dermatitis and assesses its effects on serum total immunoglobulin E, interleukin-4, and leukotriene B4.
ResearchTreatmentsTesting and diagnosis
Study · bioRxiv : the preprint server for biology · Sep 9
Intestinal uptake regulates T cell responses to dietary antigens (opens in a new tab)
Chang YT, Le HH, Morrison A, et al.
Dietary proteins induce antigen-specific immune responses, leading to oral tolerance or food allergies.
ResearchTreatments